Exosen Nasal Spray
Our intranasal spray will deliver regenerative exosomes directly to the brain, bypassing the blood-brain barrier to activate powerful neurogenesis and repair pathways - safely and non-invasively.
Neurogenesis
Our researchers have published work [1] demonstrating the effects of polarized cell infusion on cognition in old mice. We also have unpublished findings showing that exosomes from these polarized cells, delivered intranasally, markedly enhance neurogenesis, neural stem cell proliferation, and reverse age-related cognitive decline compared to naïve controls. This body of work is the scientific onramp to Exosen [2].
Figure legend: Increased neurogenesis in culture. Neural stem cells were cultures with exosomes. They propogate and differentiate to form spheres containing the stem cells (SOX2, NESTIN) and their differentiating progeny glial cells (GFAP) and Neurons (MAP2). Treatment with our propriatery exosomes increased the number and size of the neurospheres.
Life Extension
Multiple studies have shown that young-derived exosomes can extend lifespan, including work on hypothalamic stem cell–derived miRNAs [1] (top), plasma vesicles that restore mitochondrial metabolism [2] (bottom), eNAMPT-containing vesicles that delay aging in mice [3], and vesicles that rejuvenate aged rats and human senescent cells [4]. Exosen will test whether intranasal delivery of our engineered exosomes can produce similar effects. By targeting the brain - the central regulator of aging - we aim to trigger both direct neuroregeneration and systemic rejuvenation.
AI Optimization
We use a custom AI agent, Exobot, to help design optimal growth conditions and media constituents (e.g. hormones, peptides, and nutrients) that program the cells and, in turn, their exosomes for maximal efficacy. By guiding these inputs, Exobot systematically enhances the therapeutic potential of our vesicles, biasing them toward stronger neurogenic and anti-inflammatory effects.
Clinic Network
Stem cell clinics are a global schelling point. We partner with vetted clinics in special jurisdictions that support medical innovation through flexible regulatory frameworks. These regions enable early access to cutting therapies, real world data collection, and streamlined clinical trial approvals without compromising safety. By operating with these forward thinking zones, we significantly reduce time to treatment while maintaining rigorous oversight.
References
[1] Tfilin M et al., International Journal of Molecular Sciences, 2023. Polarized Anti-Inflammatory Mesenchymal Stem Cells Increase Hippocampal Neurogenesis and Improve Cognitive Function in Aged Mice.
[2] Rudnitsky E et al., Ageing Research Reviews, 2024. Stem Cell-Derived Extracellular Vesicles as Senotherapeutics.
[3] Zhang Y et al., Nature, 2017. Hypothalamic stem cells control ageing speed partly through exosomal miRNAs.Yoshida M et al., Nature Aging, 2021.
[4] Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism.
[5] Yoshida M et al., Nature Communications, 2019. Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice.
[6] El-Kasti MM et al., GeroScience, 2022. Rejuvenating effects of young extracellular vesicles in aged rats and in cellular models of human senescence.
Partner Clinics
We are collaborating with world class clinics to facilitate experimental treatments and real world validation of our therapies.
